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Sample Topic: Asthma

Asthma : Last revised in December 2013


New evidence

Evidence-based guidelines

Guidelines published since the last revision of this topic:

  • Bateman, E.D., Hurd, S.S., Barnes, P.J., et al. (2008) Global strategy for asthma management and prevention: GINA executive summary. European Respiratory Journal 31(1), 143-178. [Abstract] [Free Full-text]
  • Dombrowski, M.P., Schatz, M., and ACOG Committee on Practice Bulletins-Obstetrics (2008) ACOG practice bulletin: clinical management guidelines for obstetrician-gynecologists number 90, February 2008: asthma in pregnancy. Obstetrics and Gynecology 111(2 Pt 1), 457-464. [Abstract]
  • ICSI (2010) Diagnosis and treatment of asthma. Institute for Clinical Systems Improvement www.icsi.org [Free Full-text]
  • National Heart, Lung, and Blood Institute and National Asthma Education and Prevention Program (2007) Expert panel report 3: guidelines for the diagnosis and management of asthma. National Institutes of Health. www.nhlbi.nih.gov [Free Full-text]
  • VA/DoD Management of Asthma Working Group (2009) Management of asthma in children and adults. Department of Veterans Affairs and Department of Defense (US). www.healthquality.va.gov [Free Full-text]

Consensus statements published since the last revision of this topic:

  • Bacharier, L.B., Boner, A., Carlsen, K.H., et al. (2008) Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 63(1), 5-34. [Abstract] [Free Full-text]
  • Tarlo, S.M., Balmes, J., Balkissoon, R., et al. (2008) Diagnosis and management of work-related asthma: American College of Chest Physicians Consensus statement. Chest 134(3 Suppl), 1S-41S. [Abstract] [Free Full-text]

NICE has produced an evidence summary on new medicines for asthma:

  • NICE (2013) ESNM22: Asthma: beclometasone/formoterol (Fostair) for maintenance and reliever treatment. National Institute for Health and Care Excellence. www.nice.org.uk [Free Full-text]
  • NICE (2014) ESNM35: Asthma: fluticasone furoate/vilanterol (Relvar Ellipta) combination inhaler. National Institute for Health and Care Excellence. www.nice.org.uk [Free Full-text]

HTAs (Health Technology Assessments)

NICE health technology appraisals published since the last revision of this topic.

  • NICE (2007) Inhaled corticosteroids for the treatment of chronic asthma in children under the age of 12 years. NICE technology appraisal guidance 131. National Institute for Health and Clinical Excellence. www.nice.org.uk [Free Full-text]
  • NICE (2008) Inhaled corticosteroids for the treatment of chronic asthma in adults and in children aged 12 years and over. NICE technology appraisal guidance 138. National Institute for Health and Clinical Excellence. www.nice.org.uk [Free Full-text]
  • NICE (2010) Omalizumab for the treatment of severe persistent allergic asthma in children aged 6 to 11 years. NICE technology appraisal guidance 201. National Institute for Health and Clinical Excellence. www.nice.org.uk [Free full-text]

Health technology assessments published since the last revision of this topic.

  • CADTH (2009) Long-acting beta2-agonist and inhaled corticosteroid combination therapy for adult persistent asthma: systematic review of clinical outcomes and economic evaluation. Technology report number 122. Canadian Agency for Drugs and Technologies in Health. www.cadth.ca [Free Full-text]
  • Main, C., Shepherd, J., Anderson, R., et al. (2008) Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2agonists for the treatment of chronic asthma in children under the age of 12 years. Health Technology Assessment 12(20), 1-174. [Abstract] [Free Full-text]

Economic appraisals

Economic appraisals published since the last revision of this topic:

  • Norman, G., Faria, R., Paton, F., et al. (2013) Omalizumab for the treatment of severe persistent allergic asthma: a systematic review and economic evaluation. Health Technology Assessment 17(52), 1-342. [Abstract] [Free Full-text]

Systematic reviews and meta-analyses

Systematic reviews published since the last revision of this topic:

  • Abramson, M.J., Puy, R.M., and Weiner, J.M. (2010) Injection allergen immunotherapy for asthma (Cochrane Review). The Cochrane Library. Issue 8. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Adams, N., Lasserson, T.J., Cates, C.J., and Jones, P.W. (2007) Fluticasone versus beclomethasone or budesonide for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Adams, N.P., Bestall, J.C., Jones, P., et al. (2008) Fluticasone at different doses for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Adams, N.P., Bestall, J.C., Lasserson, T.J., et al. (2008) Fluticasone versus placebo for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Adeniyi, F.B. and Young, T. (2012) Weight loss interventions for chronic asthma (Cochrane Review). The Cochrane Library. Issue 7. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Allen, S., Britton, J., Leonardi-Bee, J. (2009) Association between antioxidant vitamins and asthma outcomes: systematic review and meta-analysis. Thorax 64(7), 610-619. [Abstract]
  • Arnold, E., Clark, C.E., Lasserson, T.J., and Wu, T. (2008) Herbal interventions for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 1. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Bahadori, K., Doyle-Waters, M.M., Marra, C., et al. (2009) Economic burden of asthma: a systematic review. BMC Pulmonary Medicine 9(1), 24. [Abstract] [Free Full-text]
  • Bailey, E.J., Kruske, S.G., Morris, P.S., et al. (2008) Culture-specific programs for children and adults from minority groups who have asthma (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Bateman, E., Nelson, H., Bousquet, J., et al. (2008) Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events. Annals of Internal Medicine 149(1), 33-42. [Abstract] [Free Full-text]
  • Beggs, S., Foong, Y.C., Le, H.C.T., et al. (2013) Swimming training for asthma in children and adolescents aged 18 years and under (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Blake, K. and Lima, J. (2011) Asthma in sickle cell disease: implications for treatment. Anemia 2011, 740235. [Abstract] [Free Full-text]
  • Bonini, M., Di Mambro, C., Calderon, M.A., et al. (2013) Beta2-agonists for exercise-induced asthma (Cochrane Review). The Cochrane Library. Issue 10. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Boyd, M., Lasserson, T.J., McKean, M.C., et al. (2009) Interventions for educating children who are at risk of asthma-related emergency department attendance (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Bravata, D.M., Gienger, A.L., Holty, J.E., et al. (2009) Quality improvement strategies for children with asthma: a systematic review. Archives of Pediatrics and Adolescent Medicine 163(6), 572-581. [Abstract] [Free Full-text]
  • Brozek, J.L., Kraft, M., Krishnan, J.A., et al. (2012) Long-acting beta2-agonist step-off in patients with controlled asthma: systematic review with meta-analysis. Archives of Internal Medicine 172(18), 1365-1375. [Abstract]
  • Bruurs, M.L., van der Giessen, L.J., and Moed, H. (2013) The effectiveness of physiotherapy in patients with asthma: a systematic review of the literature. Respiratory Medicine 107(4), 483-494. [Abstract]
  • Castro-Rodriguez, J.A. and Rodrigo, G.J. (2009) Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics 123(3), e519-e525. [Abstract] [Free Full-text]
  • Castro-Rodriguez, J.A. and Rodrigo, G.J. (2009) The role of inhaled corticosteroids and montelukast in children with mild-moderate asthma: results of a systematic review with meta-analysis. Archives of Disease in Childhood 95(5), 365-370. [Abstract]
  • Castro-Rodriguez, J.A. and Rodrigo, G.J. (2012) A systematic review of long-acting beta2-agonists versus higher doses of inhaled corticosteroids in asthma. Pediatrics 130(3), e650-e657. [Abstract]
  • Cates, C.J. and Cates, M.J. (2008) Regular treatment with salmeterol for chronic asthma: serious adverse events (Cochrane Review). The Cochrane Library. Issue 3. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cates, C.J., and Lasserson, T.J. (2010) Regular treatment with formoterol and an inhaled corticosteroid versus regular treatment with salmeterol and an inhaled corticosteroid for chronic asthma: serious adverse events (Cochrane Review). The Cochrane Library. Issue 1. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cates, C.J., Lasserson, T.J., and Jaeschke, R. (2009) Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cates, C.J., Lasserson, T.J. and Jaeschke, R. (2009) Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse effects (Cochrane Review). The Cochrane Library. Issue 3. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cates, C.J. and Lasserson, T.J. (2009) Combination formoterol and inhaled steroid versus beta2-agonist as relief medication for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 1. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cates, C.J. and Lasserson, T.J. (2009) Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cates, C.J. and Lasserson, T.J. (2009) Regular treatment with formoterol versus regular treatment with salmeterol for chronic asthma: serious adverse events (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Chauhan, B.F., Chartrand, C., and Ducharme, F.M. (2012) Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults (Cochrane Review). The Cochrane Library. Issue 12. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Chauhan, B.F., Ben Salah, R. And Ducharme, F.M. (2013) Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma (Cochrane Review). The Cochrane Library. Issue 10. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Cramer, H., Posadzki, P., Dobos, G. and Langhorst, J. (2014) Yoga for asthma: a systematic review and meta-analysis. Annals of Allergy, Asthma and Immunology epub ahead of print. [Abstract]
  • de Aguiar, M.M., da Silva, H.J., Rizzo, J.A., et al. (2013) Inhaled beclomethasone in pregnant asthmatic women – a systematic review. Allergologia et immunopathologia epub ahead of print. [Abstract]
  • Ducharme, F.M., Lasserson, T.J., and Cates, C.J. (2011) Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma (Cochrane Review). The Cochrane Library. Issue 5. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Eijkemans, M., Mommers, M., Draaisma, J.M., et al. (2012) Physical activity and asthma: a systematic review and meta-analysis. PLoS One 7(12), e50775. [Abstract] [Free Full-text]
  • El-Zein, M., Parent, M.E., Benedetti, A., and Rousseau, M.C. (2009) Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies. International Journal of Epidemiology 39(2), 469-486. [Abstract] [Free Full-text]
  • Eneli, I.U., Skybo, T., and Camargo, C.A. (2008) Weight loss and asthma: a systematic review. Thorax 63(8), 671-676. [Abstract]
  • Ernst, E. (2009) Spinal manipulation for asthma: a systematic review of randomised clinical trials. Respiratory Medicine 103(12), 1791-1795. [Abstract]
  • Etminan, M., Sadatsafavi, M., Jafari, S., et al. (2009) Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. Chest 136(5), 1316-1323. [Abstract] [Free Full-text]
  • Everhart, R.S. and Fiese, B.H. (2008) Asthma severity and child quality of life in pediatric asthma: a systematic review. Patient Education and Counseling 75(2), 162-168. [Abstract]
  • Frois, C., Wu, E.Q., Ray, S., and Colice, G.L. (2009) Inhaled corticosteroids or long-acting beta-agonists alone or in fixed-dose combinations in asthma treatment: a systematic review of fluticasone/budesonide and formoterol/salmeterol. Clinical Therapeutics 31(12), 2779-2803. [Abstract]
  • Gao, J., Gao, X., Li, W., et al. (2008) Observational studies on the effect of dietary antioxidants on asthma: a meta-analysis. Respirology 13(4), 528-536. [Abstract]
  • Garcia-Marcos, L., Castro-Rodriguez, J.A., Weinmayr, G., et al. (2013) Influence of Mediterranean diet on asthma in children: a systematic review and meta-analysis. Pediatric Allergy and Immunology 24(4), 330-338. [Abstract]
  • George, M. and Topaz, M. (2013) A systematic review of complementary and alternative medicine for asthma self-management. Nursing Clinics of North America 48(1), 53-149. [Abstract]
  • Gotzche, P.C. and Johansen, H.K. (2008) House dust mite control measures for asthma (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Hagan, J.B., Samant, S.A., Volcheck, G.W., et al. (2014) The risk of asthma exacerbation after reducing inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials. Allergy 69(4), 510-516. [Abstract]
  • Hart, K., Weatherall, M., Shirtcliffe, P., and Beasley, R. (2009) Frequency of dosing and comparative doses of mometasone furoate: a meta-analysis. Respirology 14(8), 1166-1172 [Abstract]
  • Jaeschke, R., O’Byrne, P.M., Mejza, F., et al. (2008) The safety of long acting beta agonists among patients with asthma using inhaled corticosteroids. American Journal of Respiratory and Critical Care Medicine 178(10), 1009-1016. [Abstract] [Free Full-text]
  • Jartti, T. (2008) Inhaled corticosteroids or montelukast as the preferred primary long-term treatment for pediatric asthma? European Journal of Pediatrics 167(7), 731-736. [Abstract]
  • Jat, K.R. and Chawla, D. (2012) Ketamine for management of acute exacerbations of asthma in children (Cochrane review). The Cochrane Library. Issue 11. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Jat, K.R. and Khairwa, A. (2013) Levalbuterol versus albuterol for acute asthma: a systematic review and meta-analysis. Pulmonary Pharmacology and Therapeutics 26(2), 239-48. [Abstract]
  • Jia, C.E., Zhang, H.P., Lv, Y., et al. (2013) The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: systematic review and meta-analysis. Journal of Allergy and Clinical Immunology 131(3), 695-703. [Abstract]
  • Joos, S., Miksch, A., Szecsenyi, J., et al. (2008) Montelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: a systematic review. Thorax 63(5), 453-462. [Abstract]
  • Juel, C.T., Ali, Z., Nilas, L., and Ulrik, C.S. (2012) Asthma and obesity: does weight loss improve asthma control? A systematic review. Journal of Asthma and Allergy 2012(5), 21-26. [Abstract] [Free Full-text]
  • Kramer, S., Rottier, B.L., Scholten, R.J.P.M. and Boluyt, N. (2013) Ciclesonide versus other inhaled corticosteroids for chronic asthma in children (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Lasserson, T.J., Cates, C.J., Ferrara, G., and Casali, L. (2008) Combination fluticasone and salmeterol versus fixed dose combination budesonide and formoterol for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 1. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Lim, R.H., Kobzik, L., and Dahl, M. (2010) Risk of asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS One 5(4), e10134. [Abstract] [Free Full-text]
  • Lim, A., Stewart, K., Konig, K. and George, J. (2011) Systematic review of the safety of regular preventive asthma medications during pregnancy. Annals of Pharmacotherapy 45(7-8), 931-945. [Abstract]
  • Loymans, R.J.B, Gemperli, A., Cohen, J., et al. (2014) Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis. BMJ 348, g3009. [Free Full-text]
  • Maas, T., Kaper, J., Sheikh, A., et al. (2009) Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma (Cochrane Review). The Cochrane Library. Issue 3. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Manning, P., Gibson, P.G., and Lasserson, T.J. (2008) Ciclesonide versus other inhaled steroids for chronic asthma in children and adults (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Manning, P., Gibson, P.G., and Lasserson, T.J. (2008) Ciclesonide versus placebo for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Massingham, K., Fox, S., and Smaldone, A. (2014) Asthma therapy in pediatric patients: a systematic review of treatment with montelukast versus inhaled corticosteroids. Journal of Pediatric Health Care 28(1), 51-62. [Abstract]
  • McLean, S., Chandler, D., Nurmatov, U., et al. (2010) Telehealthcare for asthma (Cochrane Review). The Cochrane Library. Issue 10. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Milan, S.J., Hart, A., and Wilkinson, M. (2013) Vitamin C for asthma and exercise-induced bronchoconstriction (Cochrane Review). The Cochrane Library. Issue 10. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Morales, D.R., Jackson, C., Lipworth, B.J., et al. (2013) Adverse respiratory effect of acute beta-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials. Chest epub ahead of print. [Abstract]
  • Nathani, N., Little, M.A., Kunst, H., et al. (2008) Churg-Strauss syndrome and leukotriene antagonist use: a respiratory perspective. Thorax 63(10), 883-888 [Abstract]
  • Ni Chroinin, M., Greenstone, I., Lasserson, T.J., and Ducharme, F.M. (2009) Addition of inhaled long-acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naive adults and children (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Ni Chroinin, M., Lasserson, T.J., Greenstone, I., and Ducharme, F.M. (2009) Addition of long-acting beta-agonists to inhaled corticosteroids for chronic asthma in children (Cochrane Review). The Cochrane Library. Issue 3. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Norman, G., Faria, R., Paton, F., et al. (2013) Omalizumab for the treatment of severe persistent allergic asthma: a systematic review and economic evaluation. Health Technology Assessment 17(52), 1-342. [Abstract] [Free Full-text]
  • Nurmatov, U., Devereux, G. and Sheikh, A. (2010) Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. Journal of Allergy and Clinical Immunology 127(3), 724-733. [Abstract]
  • Pacheco, D.R., Silva, M.J., Alexandrino, A.M., and Torres, R.M. (2012) Exercise-related quality of life in subjects with asthma: a systematic review. Journal of Asthma 49(5), 487-495. [Abstract]
  • Petsky, H.L., Cates, C.J., Li, A.M., et al. (2009) Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Postma, J., Karr, C., and Kieckhefer, G. (2009) Community health workers and environmental interventions for children with asthma: a systematic review. Journal of Asthma 46(6), 564-576. [Abstract]
  • Quon, B.S., FitzGerald, J.M., Lemiere, C., et al. (2010) Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 10. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Rank, M.A., Hagan, J.B., Park, M.A., et al. (2013) The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: a systematic review and meta-analysis of randomized controlled trials. Journal of Allergy and Clinical Immunology 131(3), 724-729. [Abstract]
  • Rodriguez, C., Sossa, M., and Lozano, J.M. (2008) Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children (Cochrane Review). The Cochrane Library. Issue 2. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Rodrigo, G.J. and Castro-Rodriquez, J.A. (2013) Daily vs. intermittent inhaled corticosteroids for recurrent wheezing and mild persistent asthma: a systematic review with meta-analysis. Respiratory Medicine 107(8), 1133-1140. [Abstract]
  • Seale, J.P., Jenkins, C., Wood-Baker, R., and Neville, A.M. (2008) Benefits of fixed-dose combination therapy with inhaled corticosteroids and long-acting bronchodilators as initial maintenance therapy in the management of asthma. Respirology 14(2), 224-229. [Abstract]
  • Shen, F.Y., Lee, M.S. and Jung, S.K. (2010) Effectiveness of pharmacopuncture for asthma: a systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine 2011; 678176. [Abstract] [Free Full-text]
  • Si, X.B., Zhang, S., Huo, L.Y., et al. (2013) Statin therapy does not improve lung function in asthma: a meta-analysis of randomized controlled trials. Journal of International Medical Research 41(2), 276-283. [Abstract]
  • Silva, D., Couto, M., Delgado, L., and Moreira, A. (2012) A systematic review of statin efficacy in asthma. Journal of Asthma 49(9), 885-894. [Abstract]
  • Sindi, A., Todd, D.C., and Nair, P. (2009) Antiinflammatory effects of long-acting beta2-agonists in patients with asthma: a systematic review and meta-analysis. Chest 136(1), 145-154. [Abstract] [Free Full-text]
  • Takkouche, B., Gonzalez-Barcala, F.J., Etminan, M., and Fitzgerald, M. (2008) Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis. Allergy 63(7), 857-864. [Abstract] [Free Full-text]
  • Teoh, L., Cates, C.J., Hurwitz, M., et al. (2012) Anticholinergic therapy for acute asthma in children (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Vandenplas, O., Dressel, H., Wilken, D., et al. (2011) Management of occupational asthma: cessation or reduction of exposure? A systematic review of available evidence. European Respiratory Journal 38(4), 804-811. [Abstract]
  • van den Oord, R.A.H.M., Sheikh, A. (2009) Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis. BMJ 339, b2433. [Abstract] [Free Full-text]
  • van der Wouden, J.C., Uijen, J.H.J.M., Bernsen, R.M.D., et al. (2008) Inhaled sodium cromoglycate for asthma in children (Cochrane Review). The Cochrane Library. Issue 4. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Vliagoftis, H., Kouranos, V.D., Betsi, G.I., et al. (2008) Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials. Annals of Allergy Asthma and Immunology 101(6), 570-579. [Abstract]
  • Wang, Q., Yu, C., and Sun, Y. (2013) The association between asthma and Helicobacter pylori: a meta-analysis. Helicobacter 18(1), 41-53. [Abstract]
  • Wanrooij, V.H., Willeboordse, M., Dompeling, E., and Kant, K.D. (2013) Exercise training in children with asthma: a systematic review. British Journal of Sports Medicine epub ahead of print. [Abstract]
  • Watts, K., and Chavasse, R.J.P.G. (2012) Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 5. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Weatherall, M., Clay, J., James, K., et al. (2009) Dose-response relationship of inhaled corticosteroids and cataracts: a systematic review and meta-analysis. Respirology 14(7), 983-990. [Abstract]
  • Welsh, E.J., Hasan, M., and Li, P. (2011) Home-based educational interventions for children with asthma (Cochrane Review). The Cochrane Library. Issue 10. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Welsh, E.J., and Cates, C.J. (2010) Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma (Cochrane Review). The Cochrane Library. Issue 9. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]
  • Wijesinghe, M., Weatherall, M., Perrin, K., et al (2009) Risk of mortality associated with formoterol: a systematic review and meta-analysis. European Respiratory Journal 34(4), 803-811. [Abstract] [Free Full-text]
  • Zairina, E., Stewart, K., Abramson, M.J and George, J. (2014) The effectiveness of non-pharmacological healthcare interventions for asthma management during pregnancy: a systematic review. BMC Pulmonary Medicine 14(1), 46. [Abstract] [Free Full-text]
  • Zhang, J., Li, X., Xu, J., and Ernst, E. (2012) Laser acupuncture for the treatment of asthma in children: a systematic review of randomized controlled trials. Journal of Asthma 49(7), 773-777. [Abstract]
  • Zhang, L., Axelsson, I., Chung, M. and Lau, J. (2011) Dose response of inhaled corticosteroids in children with persistent asthma: a systematic review. Pediatrics 127(1), 129-138. [Abstract] [Free Full-text]
  • Zheng, X., Guan, W., Zheng, J., et al. (2012) Smoking influences response to inhaled corticosteroids in patients with asthma: a meta-analysis. Current Medicine Research and Opinion 28(11), 1791-1798. [Abstract]
  • Zhou, Y., Yang, M., and Rong Dong, B. (2012) Monosodium glutamate avoidance for chronic asthma in adults and children (Cochrane Review). The Cochrane Library. Issue 6. John Wiley & Sons, Ltd. www.thecochranelibrary.com [Free Full-text]

Primary evidence

Randomized controlled trials published since the last revision of this topic:

  • Abramson, M.J., Schattner, R.L., Sulaiman, N.D., et al. (2010) Do spirometry and regular follow-up improve health outcomes in general practice patients with asthma or COPD? A cluster randomised controlled trial. Medical Journal of Australia 193(2), 104-109. [Abstract] [Free Full-text]
  • American Lung Association Asthma Clinical Research Centers (2009) Efficacy of esomeprazole for treatment of poorly controlled asthma. New England Journal of Medicine 360(15), 1487-1499. [Abstract] [Free Full-text]
  • Chang, A.B., Clark, R., Sloots, T.P., et al. (2008) A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial. Medical Journal of Australia 189(6), 306-310. [Abstract] [Free Full-text]
  • de Jongste, J.C., Carraro, S., Ho, W.C., et al. (2009) Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. American Journal of Respiratory and Critical Care Medicine 179(2), 93-97. [Abstract] [Free Full-text]
  • Haldar, P., Brightlin, C.E., Hargadon, B., et al. (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. New England Journal of Medicine 360(10), 973-984. [Abstract] [Free Full-text]
  • Holbrook, J.T., Wise, R.A., Gold, B.D. et al. (2012) Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA 307(4), 373-381. [Abstract]
  • Howden-Chapman, P., Pierse, N., Nicholls, S., et al. (2008) Effects of improved home heating on asthma in community dwelling children: randomised controlled trial. BMJ 337, a1411. [Abstract] [Free Full-text]
  • Janson, S.L., McGrath, K.W., Covington, J.K., et al. (2009) Individualized asthma self-management improves medical adherence and markers of asthma control. Journal of Allergy and Clinical Immunology 123(4), 840-846. [Abstract] [Free Full-text]
  • Kerwin, E.M., Oppenheimer, J.J., LaForce, C., et al. (2009) Efficacy and tolerability of once-daily budesonide/formoterol pressurized metered-dose inhaler in adults and adolescents with asthma previously stable with twice-daily budesonide/formoterol dosing. Annals of Allergy, Asthma and Immunology 103(1), 62-72. [Abstract]
  • Lanier, B., Bridges, T., Kulus, M., et al (2009) Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma. Journal of Allergy and Clinical Immunology 124(6), 1210-1216. [Abstract]
  • Lemanske Jr, R.F., Mauger, D.T., Sorkness, C.A., et al. (2010) Step-up therapy for children with uncontrolled asthma while receiving inhaled corticosteroids. New England Journal of Medicine 362(11), 975-985 [Abstract] [Free Full-text]
  • Lenney, W., McKay, A., Tudur Smith, C., et al. (2013) Management of Asthma in School Age Children on Therapy (MASCOT): a randomised, double-blind, placebo-controlled, parallel study of efficacy and safety. Health Technology Assessment 17(4), 1-218. [Abstract]
  • Mancuso, C.A., Choi, T.N. Westermann, H., et al. (2012) Increasing physical activity in patients with asthma through positive affect and self-affirmation: a randomized trial. Archives of Internal Medicine 172(4), 337-343. [Abstract]
  • Nair, P., Pizzichini, M.M., Kjarsgaard, M., et al. (2009) Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. New England Journal of Medicine 360(10), 985-993. [Abstract] [Free Full-text]
  • Oborne, J., Mortimer, J., Hubbard, R.B., et al. (2009) Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double blind, placebo controlled, parallel group, clinical trial. American Journal of Respiratory and Critical Care Medicine 180(7), 598-602. [Abstract] [Free Full-text]
  • Ryan, D., Price, D., Musgrave, S.D., et al. (2012) Clinical and cost effectiveness of mobile phone supported self monitoring of asthma: multicentre randomised controlled trial. BMJ 344, e1756. [Abstract] [Free Full-text]
  • Schuh, S., Willan, A.R., Stephens, D., et al. (2009) Can montelukast shorten prednisolone therapy in children with mild to moderate acute asthma? A randomized controlled trial. Journal of Pediatrics 155(6), 795-800. [Abstract]
  • Skoner, D.P., Maspero, J., Banerji, D., and Ciclesonide Pediatric Growth Study Group (2008) Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma. Pediatrics 121(1), e1-14. [Abstract] [Free Full-text]
  • Strunk, R.C., Bacharier, L.B., Phillips, B.R., et al. (2008) Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study. Journal of Allergy and Clinical Immunology 122(6), 1138-1144. [Abstract] [Free Full-text]
  • Strunk, R.C., Sternberg, A.L., Szefler, S.J., et al. (2009) Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. Journal of Pediatrics 154(5), 682-687. [Abstract] [Free Full-text]
  • Szefler, S.J., Mitchell, H., Sorkness, C.A., et al. (2008) Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 372(9643), 1065-1072. [Abstract] [Free Full-text]
  • Thomas, M., McKinley, R.K., Mellor, S., et al. (2009) Breathing exercises for asthma: a randomised controlled trial. Thorax 64(1), 55-61. [Abstract] [Free Full-text]
  • Turpeinen, M., Nikander, K., Pelkonen, A.S., et al. (2008) Daily versus as-needed inhaled corticosteroid for mild persistent asthma (the Helsinki early intervention childhood asthma study). Archives of Disease in Childhood 93(8), 654-659. [Abstract] [Free Full-text]
  • Vempati, R., Bijlani, R.L., and Deepak, K.K. (2009) The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial. BMC Pulmonary Medicine 9(1), 37. [Abstract] [Free Full-text]
  • Vuillermin, P.J., Robertson, C.F., Carlin, J.B., et al. (2010) Parent initiated prednisolone for acute asthma in children of school age: randomised controlled crossover trial. BMJ 340, c843. [Abstract] [Free Full-text]
  • Wechsler, M.E., Kunselman, S.J., Chinchilli, V.M., et al. (2009) Effect of beta2-adrenergic receptor polymorphism on response to long-acting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet 374(9703), 1754-1764. [Abstract] [Free Full-text]
  • Wright, G.R, Howieson, S., McSharry, C., et al. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy 64(11), 1671-1680. [Abstract] [Free Full-text]

Observational studies published since the last revision of this topic:

  • Bakhireva, I.N., Schatz, M., Jones, K.L., et al. (2008) Asthma control during pregnancy and the risk of preterm delivery or impaired fetal growth. Annals of Allergy, Asthma & Immunology 101(2), 137-143. [Abstract]
  • Busse, W.W., Morgan, W.J., Gergen, P.J., et al. (2011) Randomized trial of omalizumab (Anti-IgE) for asthma in inner-city children. New England Journal of Medicine 364(11), 1005-1015. [Abstract] [Free Full-text]
  • de Vries, F., Setakis, E., Zhang, B., and van Staa, T.P. (2010) Long-acting beta2-agonists in adult asthma and the pattern of risk of death and severe asthma outcomes: a study with the General Practice Research Database. European Respiratory Journal 36(3), 494-502. [Abstract] [Free Full-text]
  • Kelly, H.W., van Natta, M.L., Covar, R.A., et al. (2008) Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood asthma management program (CAMP) study. Pediatrics 122(1), e53-e61. [Abstract] [Free Full-text]
  • Lapi, F., Kezouh, A., Suissa, S., and Ernst, P. (2013) The use of inhaled corticosteroids and the risk of adrenal insufficiency. European Respiratory Journal 42(1), 79-86. [Abstract]
  • Lin, S., Munsie, J.P., Herdt-Losavio, M.L., et al. (2012) Maternal asthma medication use and risk of selected birth defects. Pediatrics 129(2), e316-e324. [Abstract]
  • Mai, X.M., Langhammer, A., Chen, Y., et al. (2013) Cod liver oil intake and incidence of asthma in Norwegian adults – the HUNT study. Thorax 68(1), 25-30. [Abstract]
  • Martinez, F.D., Chinchilli, V.M., Morgan, W.J., et al. (2011) Use of beclomethasone dipropionate as a rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet 377(9766), 650-657. [Abstract]
  • Price, D., Musgrave, S., Wilson, E., et al. (2011) A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study). Health Technology Assessment 15(21), 1-132. [Free Full-text]
  • Price, D., Musgrave, S.D., Shepstone, L., et al. (2011) Leukotriene antagonists as first-line or add-on asthma-controller therapy. New England Journal of Medicine 364(18), 1695-1707. [Abstract] [Free Full-text]
  • Ramsay, C.F., Pearson, D., Mildenhall, S. and Wilson, A.M. (2010) Oral montelukast in acute asthma exacerbations: a randomised, double-blind, placebo-controlled trial. Thorax 66(1), 7-11. [Abstract]
  • Risnes, K.R., Belanger, K., Murk, W. and Bracken, M.B. (2010) Antibiotic exposure by 6 months and asthma and allergy at 6 years: findings in a cohort of 1401 US children. American Journal of Epidemiology 173(3), 310-318. [Abstract] [Free Full-text]
  • Shaaban, R., Zureik, M., Soussan, D., et al. (2008) Rhinitis and onset of asthma: a longitudinal population-based study. Lancet 372(9643), 1049-1057. [Abstract]
  • Stern, D.A., Morgan, W.J., Halonen, M., et al. (2008) Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 372(9643), 1058-1064. [Abstract] [Free Full-text]
  • Tata, L.J., Lewis, S.A., McKeever, T.M., et al. (2008) Effect of maternal asthma, exacerbations and asthma medication use on congenital malformations in offspring: a United Kingdom population-based study. Thorax 63(11), 981-987. [Abstract]
  • To, T., Gershon, A., Wang, C., et al. (2007) Persistence and remission in childhood asthma: a population-based asthma birth cohort study. Archives of Pediatrics and Adolescent Medicine 161(12), 1197-1204. [Abstract] [Free Full-text]
  • Vestergaard, P., Rejnmark, L., and Mosekilde, L. (2007) Fracture risk in patients with chronic lung diseases treated with bronchodilator drugs and inhaled and oral corticosteroids. Chest 132(5), 1599-1607. [Abstract] [Free Full-text]
  • Wu, A.C., Tantisira, K., Li, L., et al. (2012) Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. American Journal of Respiratory and Critical Care Medicine 186(6), 508-513. [Abstract]

Post hoc analysis of randomized controlled trials published since the last revision of this topic:

  • Barr, R.G., Kurth, T., Stampfer, M.J., et al. (2007) Aspirin and decreased adult-onset asthma: randomized comparisons from the physicians’ health study. American Journal of Respiratory and Critical Care Medicine 175(2), 120-125. [Abstract] [Free Full-text]
  • Kurth, T., Barra, R.G., Ganziano, J.M., and Buring, J. (2008) Randomised aspirin assignment and risk of adult-onset asthma in the Women’s Health Study. Thorax 63(6), 514-418. [Abstract] [Free Full-text]